2wy7

About this Structure
2WY7 is a 2 chains structure with sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.

2WY7 has a glycerol ligand chemical component.

When Sbi-IV and C3 interact while in the presence of domain III, a Sbi-III-IV-C3 adduct is formed followed by futile fluid phase consumption of C3. (Clark, E.A., et al)

Clark, E.A., et al note in their conclusion, "[the aforementioned result raises] the possibility of designing Sbi-based therapeutics for the treatment of complment-mediated diseases."

Related PDB Entries

 * 1C3D
 * 1GHQ
 * 1W2S
 * 2A73
 * 2A74
 * 2HR0
 * 2WII
 * 2WIN
 * 2WY8

Reference
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